Medicine Information

g-cromo

Name: g-cromo
Brand: g-cromo
Rating: 4.5 (117 reviews)

Eye Drop (Ophthalmic Solution)2% (w/v)Antiallergic, Mast Cell StabilizerATC: S01GX01

Generic Name

Cromolyn Sodium Ophthalmic Solution

Manufacturer

Multiple manufacturers (generic)

Country

Bangladesh (Local market specific)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
g cromo 2 eye drop	৳ 50.00	N/A

Description

Overview of the medicine

Cromolyn Sodium is an ophthalmic solution used to prevent and treat ocular symptoms of allergic conjunctivitis, including itching, burning, and redness. It works by stabilizing mast cells and preventing the release of inflammatory mediators.

Uses & Indications

Allergic conjunctivitis

Vernal keratoconjunctivitis

Vernal conjunctivitis

Giant Papillary Conjunctivitis (GPC)

Dosage

Adults

1-2 drops in each eye 4-6 times daily at regular intervals. Continued use is necessary to maintain effect.

Elderly

No specific dosage adjustment required. Use as for adults.

Renal_impairment

No dosage adjustment necessary due to minimal systemic absorption.

How to Take

For ophthalmic use only. Instill drops into the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface to prevent contamination. If using other eye medications, wait at least 5-10 minutes between applications. Remove contact lenses before application and wait at least 15 minutes before reinserting.

Mechanism of Action

Cromolyn Sodium acts as a mast cell stabilizer. It inhibits the degranulation of sensitized mast cells that occurs after exposure to specific antigens. This prevents the release of histamine and other inflammatory mediators (e.g., leukotrienes, prostaglandins) from mast cells, thereby reducing the allergic response.

Pharmacokinetics

Onset

Therapeutic effect may take several days to a few weeks (up to 4 weeks) to become apparent.

Excretion

Systemically absorbed cromolyn sodium is rapidly and almost completely excreted unchanged in the urine and bile in approximately equal amounts.

Half life

Not well-defined for ocular use due to minimal systemic absorption. Systemic half-life is approximately 80 minutes.

Absorption

Systemic absorption is minimal following ophthalmic administration. Less than 0.03% of a dose is absorbed systemically.

Metabolism

Not metabolized; excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to Cromolyn Sodium or any component of the formulation.

Drug Interactions

Ophthalmic corticosteroids

No significant known interactions when used concomitantly. May provide additive benefits.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Overdose via ocular administration is unlikely due to minimal systemic absorption. In the event of accidental ingestion or excessive ocular use, supportive measures may be initiated if any systemic effects occur, though these are rare.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cromolyn sodium is poorly absorbed and excretion into breast milk is expected to be minimal; likely safe during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml bottle10 ml bottle

Shelf Life

Typically 24-36 months for unopened bottles. Discard 28 days after opening.

Availability

Available in pharmacies

Approval Status

Approved (for allergic conjunctivitis)

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Cromolyn sodium has been extensively studied in clinical trials demonstrating its efficacy and safety for the prevention and treatment of allergic conjunctivitis. Its mechanism of mast cell stabilization is well-established.

Lab Monitoring

Routine lab monitoring is not required for Cromolyn Sodium ophthalmic solution.

Doctor Notes

Emphasize the prophylactic nature of cromolyn sodium; patients should be advised to use it regularly for sustained benefit, particularly before anticipated allergen exposure.
Remind patients that the full therapeutic effect may not be immediate and can take up to several weeks.
Counsel on proper instillation technique to avoid contamination and maximize efficacy.

Patient Guidelines

Use regularly as prescribed for best results, even if symptoms improve.
Do not wear soft contact lenses during treatment; remove them before application and wait 15 minutes before reinsertion.
Avoid touching the dropper tip to your eye or any surface to prevent contamination.
If you experience severe irritation or allergic reaction, discontinue use and consult your doctor.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

This medicine may cause temporary blurred vision upon instillation. Exercise caution when driving or operating machinery until your vision clears.

Lifestyle Advice

Identify and avoid known allergens (e.g., pollen, pet dander, dust mites) that trigger your allergic conjunctivitis.
Maintain good hygiene, including regular hand washing, to prevent eye infections.
Consider using sunglasses outdoors to reduce exposure to environmental allergens.