Medicine Information

K-Lac

Name: K-Lac
Brand: K-Lac
Rating: 4.5 (117 reviews)

Injection30 mgNon-Steroidal Anti-inflammatory Drug (NSAID)ATC: M01AB15

Generic Name

Ketorolac Tromethamine

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
k lac 30 mg injection	৳ 55.00	N/A

Description

Overview of the medicine

K-Lac 30 mg Injection is a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderately severe acute pain requiring opioid-level analgesia.

Uses & Indications

Short-term management of moderately severe acute pain

Post-operative pain management

Renal colic

Dosage

Adults

Initial dose 30 mg IM or IV, followed by 30 mg every 6 hours, not exceeding 120 mg/day for IM or 60 mg/day for IV in patients >65 kg. Maximum duration of treatment is 5 days.

Elderly

Reduce dose to 15 mg every 6 hours (max 60 mg/day).

Renal_impairment

Contraindicated in advanced renal impairment. For mild to moderate, dose reduction to 15 mg every 6 hours (max 60 mg/day).

How to Take

Administer intravenously or intramuscularly. IV doses should be administered over a minimum of 15 seconds. IM doses should be given slowly and deeply into a large muscle.

Mechanism of Action

Ketorolac inhibits prostaglandin synthesis by reversibly inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This results in reduced inflammation, pain, and fever.

Pharmacokinetics

Onset

Analgesic effect usually within 30 minutes after IM/IV administration.

Excretion

Primarily renal (approximately 91%), with some fecal excretion (6%).

Half life

Approximately 4-6 hours (varies with age and renal function).

Absorption

Rapid and complete absorption after IM administration. Peak plasma concentration achieved within 30-60 minutes.

Metabolism

Primarily hepatic via hydroxylation and glucuronidation.

Side Effects

Contraindications

Active peptic ulcer disease or gastrointestinal bleeding
History of gastrointestinal bleeding or perforation related to NSAID use
Advanced renal impairment
Hypersensitivity to ketorolac or other NSAIDs
Aspirin-sensitive asthma
Cerebrovascular bleeding or bleeding diathesis
Concomitant use with other NSAIDs, aspirin, anticoagulants
Peri-operative pain in coronary artery bypass graft (CABG) surgery
Pregnancy (third trimester) and labor/delivery

Drug Interactions

Lithium

Increased lithium plasma levels and toxicity.

Diuretics

Reduced natriuretic effect and increased risk of renal impairment.

Methotrexate

Increased methotrexate toxicity.

Other NSAIDs or aspirin

Increased risk of GI adverse effects.

Warfarin, Heparin, other anticoagulants

Increased risk of bleeding.

ACE inhibitors, Angiotensin II Receptor Blockers (ARBs)

Reduced antihypertensive effect and increased risk of renal impairment.

Storage

Store below 30°C. Protect from light and freezing. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if recent oral ingestion (not applicable for injection overdose).

Pregnancy & Lactation

Contraindicated during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus and inhibition of uterine contractions. Use during early pregnancy and lactation only if potential benefits outweigh risks, and with caution.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial per pack5 vials per pack

Shelf Life

24-36 months when stored as recommended.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available (off-patent)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of Ketorolac for acute pain management, particularly post-operative pain. Further studies may explore its role in specific patient populations or novel administration routes.

Lab Monitoring

Monitor renal function (creatinine, BUN)
Monitor liver function tests (ALT, AST)
Monitor complete blood count (CBC) for signs of anemia or bleeding
Monitor coagulation parameters (PT/INR, aPTT) especially with concomitant anticoagulant use

Doctor Notes

Strictly for short-term (<5 days) management of acute moderate to severe pain.
Carefully assess renal and cardiovascular risk factors before and during treatment.
Avoid concomitant use with other NSAIDs or anticoagulants due to increased bleeding risk.
Elderly patients and those with renal impairment require dose adjustment and close monitoring.

Patient Guidelines

This injection is for short-term use only (maximum 5 days).
Report any signs of stomach pain, black stools, or unusual bleeding/bruising immediately.
Avoid taking other NSAIDs or aspirin without consulting your doctor.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

As this medicine is typically administered by a healthcare professional in a hospital or clinic setting, a missed dose is unlikely. If a scheduled dose is missed, inform your doctor immediately.

Driving Precautions

K-Lac may cause dizziness, drowsiness, or visual disturbances. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.