Medicine Information

Lansomax

Name: Lansomax
Brand: Lansomax
Rating: 4.5 (117 reviews)

Capsule30 mgProton Pump Inhibitor (PPI)ATC: A02BC03

Generic Name

Lansoprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lansomax 30 mg capsule	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Lansoprazole is a proton pump inhibitor (PPI) used to treat and prevent various conditions involving excess stomach acid, such as stomach ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.

Uses & Indications

Gastroesophageal Reflux Disease (GERD), including erosive esophagitis

Treatment of duodenal ulcers

Treatment of gastric ulcers

Eradication of Helicobacter pylori (in combination with antibiotics)

Treatment of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions

Prevention of NSAID-associated gastric ulcers

Dosage

Adults

For GERD: 30 mg once daily for up to 8 weeks. For duodenal ulcer: 15 mg once daily for 4 weeks. For gastric ulcer: 30 mg once daily for 8 weeks. For H. pylori eradication: 30 mg twice daily (in combination therapy).

Elderly

No specific dose adjustment is generally required, but monitor for adverse effects.

Renal_impairment

No dose adjustment is generally required.

Hepatic_impairment

Dose reduction may be considered in severe hepatic impairment (e.g., maximum 15 mg daily).

How to Take

Take orally, usually once daily before a meal (e.g., 30 minutes before breakfast). Swallow the capsule whole; do not chew or crush. If difficulty swallowing, capsules may be opened and granules mixed with a small amount of applesauce or juice.

Mechanism of Action

Lansoprazole works by irreversibly binding to and blocking the H+/K+-ATPase enzyme (the proton pump) in the gastric parietal cells. This action effectively reduces the secretion of gastric acid, leading to a decrease in stomach acid levels.

Pharmacokinetics

Onset

Acid suppression begins within 1-2 hours.

Excretion

Approximately 1/3 is excreted in urine and 2/3 in feces as inactive metabolites.

Half life

Plasma elimination half-life is 1.5-2 hours, but its pharmacodynamic effect is much longer due to irreversible binding.

Absorption

Rapidly absorbed after oral administration. Bioavailability is high (around 80-90%). Peak plasma concentrations are achieved within 1.5-2 hours.

Metabolism

Extensively metabolized in the liver via the cytochrome P450 enzyme system, primarily by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to lansoprazole or any excipients in the formulation.
Co-administration with atazanavir or nelfinavir due to significant reduction in their bioavailability.

Drug Interactions

Digoxin

Increased absorption of digoxin due to increased gastric pH.

Warfarin

Possible increase in INR and prothrombin time, requiring monitoring.

Tacrolimus

Increased plasma concentrations of tacrolimus, requiring monitoring.

Clopidogrel

Reduced antiplatelet effect of clopidogrel, increasing cardiovascular risk.

Methotrexate

Increased methotrexate levels, particularly with high-dose methotrexate, leading to potential toxicity.

Iron salts, Ketoconazole, Itraconazole, Erlotinib

Decreased absorption due to increased gastric pH.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

There is no specific antidote for lansoprazole overdose. Treatment should be symptomatic and supportive. Lansoprazole is not significantly removed by hemodialysis.

Pregnancy & Lactation

Pregnancy Category B. Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Limited data suggest minimal transfer into breast milk; use with caution during lactation and consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per strip30 capsules per box (3 strips of 10)

Shelf Life

Typically 24 to 36 months from the date of manufacture, specific to manufacturer.

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have demonstrated lansoprazole's efficacy in healing and preventing various acid-related disorders, supporting its use as a first-line therapy for many conditions.

Lab Monitoring

Monitor serum magnesium levels in patients on long-term therapy (especially with diuretics).
Consider bone mineral density assessment in very long-term use due to increased fracture risk.
Monitor for Vitamin B12 deficiency with prolonged use (>3 years).

Doctor Notes

Educate patients on the proper administration of PPIs and the importance of adhering to prescribed duration.
Be mindful of potential drug interactions, especially with clopidogrel and methotrexate.
Consider de-prescribing or reducing PPI dose for long-term users when clinically appropriate, and monitor for adverse effects associated with long-term use.

Patient Guidelines

Take exactly as prescribed by your doctor. Do not change the dose or stop the medication without consulting your doctor.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Seek medical attention if you experience severe diarrhea, persistent abdominal pain, or any unusual symptoms.
Do not crush or chew the capsule; swallow it whole.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Lansoprazole may cause dizziness, fatigue, or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Avoid trigger foods such as spicy, fatty foods, caffeine, and acidic beverages if they worsen your symptoms.
Elevate the head of your bed if you experience nighttime GERD symptoms.
Maintain a healthy weight and avoid smoking to help manage acid reflux.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Lanzol (ACI Limited)Lanzop (Beximco Pharma)Loprezol (Incepta Pharmaceuticals)Omezol (Aristopharma Ltd.) - Note: Omezol is Omeprazole, not Lansoprazole, included as a common PPI alternative.